Biological Scientist IV - Pulmonary

About the role

The Division of Pulmonary, Critical Care & Sleep Medicine is accepting applications for a Biological Scientist IV. The position will reside within the Division’s Alpha-1 Antitrypsin Laboratory and will report directly to Dr. Karina Serban, the laboratory director and an experienced physician-scientist in the field of Alpha-1 deficiency and chronic obstructive pulmonary disease (COPD).

Responsibilities

• Human and murine tissue processing and epithelial cell isolation and precision cut lung slices (PCLS)-related Experiments
• Develop novel approaches and analytical tools as required to harvest and maintain epithelial cells and PCLSs cultures derived from human explanted lungs and murine lungs.
• Design and develop dose escalation studies involving alveolar organoids and PCLSs cultures in accordance with IRB and IBC protocols.
• Collect, dissect, examine and interpret results of human and murine epithelial cells and tissue harvest.
• Develop, organize and conduct immunofluorescence and FACS analysis and data interpretation.
• Design and direct metabolism assays (Seahorse), to include oversight of technicians performing testing, review and interpretation of results.
• Provide intellectual input as to troubleshooting strategies utilized in organoids and PCLS cultures.
• Participate in bio-product development to include initial designs, pilot experiments, and collaborating with the Office of Technology and Licensing for assurance of appropriate patents.
• Create or modify web-based tools and test potentially new software to provide statistical and computational tools for big data interpretation.

Qualifications

• Analyze and interpret data, prepare graphs and figures for meetings and grant submissions.
• Present data and manuscripts in weekly lab meeting and annually in divisional meetings.
• Supervise other scientists and undergraduate students.
• Collaborate with the lung transplant team and other research groups on campus.
• Interact and coordinate with off-campus collaborators on samples shipments, common online meetings, and in-person visits.
• Prepare a quarterly report on the performance of the scientists and students, under direct supervision.

Benefits

Commensurate with education and experience

Pay

$70,000 - $92,200

Schedule

N/A