Biochemist I/II - Conjugation

Job Summary

BioLegend is seeking a Biochemist to perform antibody–fluorophore conjugations from small-scale development batches to large-scale production lots. The role involves strong technical proficiency in conjugation chemistry, consistent execution, excellent documentation practices, and active participation in continuous improvement initiatives.

About the Role

This role requires a strong understanding of conjugation chemistry and purification techniques, experience with light-sensitive fluorophores, and familiarity with automation and digital tools. The Biochemist II is expected to be comfortable with semi-automated instrumentation and electronic batch records.

Responsibilities

• Perform antibody–dye conjugations across scales
• Protect light-sensitive fluorophores during reaction and purification
• Purify conjugates via SEC, desalting, and/or affinity chromatography
• Calculate concentrations, D/P ratios, yields, and other key quality metrics
• Drive yield and passing rate improvements
• Operate, maintain, and troubleshoot lab equipment
• Support semi-automated instrumentation and electronic batch records
• Support adoption of automation and AI-enabled tools
• Review, verify, and update SOPs, batch records, and compliance documentation
• Participate in troubleshooting, root-cause investigations, and continuous improvement and lab safety initiatives
• Provide training to team members
• Contribute to other projects or responsibilities as needed

Requirements

• Associate's degree in Biochemistry, Chemistry, Biotechnology, or related scientific field with at least 2 years of experience in biotech manufacturing
• Preferably a Bachelor's degree in Biology, Chemistry, or a related scientific discipline with up to 1 year of experience in biotech product development or manufacturing
• Strong understanding of conjugation chemistry and purification techniques
• Experience handling light-sensitive fluorophores during reaction and purification while maintaining product integrity
• Experience with multiple conjugation chemistries
• Exposure to automation, SEC, and electronic batch records
• Experienced in manufacturing under ISO/GMP environment

Qualifications

• Currently authorized to work in the United States on a full-time basis for any employer
• Ability to work in a laboratory environment with occasional data entry on a computer
• Occasional exposure to a warehouse environment

Skills

• Technical proficiency in conjugation chemistry and purification techniques
• Experience with light-sensitive fluorophores
• Familiarity with automation and digital tools
• Experience with SEC and electronic batch records
• Manufacturing under ISO/GMP environment

Benefits

We offer a competitive and comprehensive benefits package, including medical, dental, and vision insurance options, life and disability insurance, paid time-off, parental benefits, compassionate care leave, and a 401(k) with company match. Additionally, we provide an Employee Stock Purchase Plan.