Associate Scientist II, Next Wave Biology

Responsibilities

• Contribute to study design and independently execute studies to characterize molecules for RNAi therapeutic delivery to a diverse array of tissues, in rodent disease models, WT mice or cell-based models
• Develop and conduct assays such as qPCR, western blot, and ELISA, in support of in vivo and in vitro studies, troubleshooting when necessary
• Perform in vitro cell-based assays to characterize drug activity, including efforts to optimize novel culture systems
• Perform in vivo procedures in rodents, including administration of therapeutics, evaluation of functional outcomes and tissue collection, via established methodologies
• Analyze, interpret and present data to groups within and outside of Next Wave Biology
• Maintain high quality data entry into electronic lab notebooks and perform data analysis in a timely manner to prepare clearly articulated experimental reports and presentations
• Develop and share Standard Operating Procedures (SOPs)/protocols for novel methods
• Maintain a safe and clean working environment by complying with procedures, rules, and regulations
• Adapt quickly to changing priorities in a dynamic work environment
• Effectively and proactively multi-task and operate collaboratively within a team-based environment
• Communicate openly and directly within and across teams and management and demonstrate the ability to effectively manage conflict

Qualifications

• Minimum B.S. degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, Biochemistry, Bioengineering or Genetics
• 1+ years of experience in laboratory research in industrial or academic settings, including hands-on experience performing cell/tissue culture and performing studies involving rodents
• Proficiency in RNA/DNA/protein extraction and analysis techniques, including qPCR, western blotting and ELISA
• Working knowledge of standard Microsoft Office applications including Excel, Outlook, PowerPoint, Word and GraphPAD Prism
• Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)
• Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions, solve challenging problems and generate clear reports
• Must be flexible, open to new tasks and challenges and able to work on tight deadlines
• Effective written and oral communication skills
• Exceptional interpersonal skills and the ability to function at a high capacity within a fast-paced team environment across functional areas
• Excellent attention to detail, organizational skills, eagerness to learn, and the ability to follow written and verbal instruction
• Advanced rodent handling skills (subcutaneous/intravenous dosing, blood collection, and necropsy/dissection expertise) is strongly preferred
• Experience evaluating rodent disease models is a plus
• Experience working with in vivo or in vitro models of skeletal or cardiac muscle disease is a plus