Associate Scientist I, Small Scale Synthesis

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. Arrowhead’s RNAi-based therapeutics leverage the natural pathway of gene silencing, enabling the potential to address conditions across virtually any therapeutic area. The company’s clinical pipeline targets diseases in the liver and lung, with a promising preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

Arrowhead is seeking an Associate Scientist I to join the Discovery Chemistry department, focusing primarily on oligonucleotide synthesis, purification, and analytical chemistry in support of specific program goals. This role contributes to the success of Arrowhead's programs as part of a collaborative team of scientists.

Responsibilities

• Perform synthesis, purification, and analysis of oligonucleotides.
• Maintain a well-documented laboratory notebook.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Manage time effectively to meet deadlines.
• Adhere to safe laboratory practices.
• Assist with maintenance of bioconjugate and oligonucleotide inventory.

Requirements

• B.S. in Chemistry or Biochemistry, with an excellent understanding of organic and analytical chemistry; or equivalent.
• Relevant experience working in a chemistry laboratory.
• Experience with a wide range of analytical techniques, especially HPLC.
• Ability to quickly learn new procedures and techniques.

Qualifications

• Experience with large-molecule synthetic targets (especially oligonucleotides), in an academic or industry setting.
• Previous experience in a pharmaceutical setting.

Pay

$60,000 USD - $68,000 USD (Wisconsin pay range)

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.