Associate Scientist: Downstream Process Development

Passionate about analytical chemistry and process development? Join a team advancing cutting-edge oligonucleotide manufacturing technologies in Cambridge, MA.

About the role

The Associate Scientist II will join the CMC - DS Process Development Group, supporting process development efforts to incorporate novel chemistries into the manufacturing platform.

Responsibilities

• Support oligonucleotide synthesis method development, optimization, and scale-up
• Support downstream processing method development
• Execute in-process analytical testing
• Partner with research and process scientists to develop robust processes for novel chemistries
• Maintain strong laboratory documentation and record-keeping
• Maintain a safe, clean, and orderly laboratory environment
• Assist with routine laboratory and equipment maintenance

Requirements

• BS in Chemistry or Chemical Engineering
• Process development experience/background
• Strong analytical chemistry background and hands-on laboratory experience
• Chemistry background with experience running analytical testing, particularly LC/HPLC
• Understanding of analytical techniques such as pH, Osmolality, Conductivity, HPLC, and LC-MS
• Strong laboratory documentation and record-keeping practices

Skills

• Knowledge of oligonucleotide manufacturing, including: Phosphoramidite chemistry, Chromatography, and Ultrafiltration
• Experience with relevant analytical testing software, e.g., Agilent and UNICORN laboratory software