Associate Scientist, CAR Discover- Lilly Gene Therapy

Job Responsibilities

• Lead the design and execution of experiments for the discovery and characterization of novel CAR constructs.
• Develop and implement innovative strategies for CAR optimization, including antigen-binding domains, costimulatory signaling, and intracellular signaling domains.
• Apply molecular biology techniques (e.g., cloning, primer design, sequencing) for CAR construct generation and modification.
• Perform in vitro functional assays (e.g., cytotoxicity, cytokine production, proliferation, activation) using primary human T cells and various tumor cell lines.
• Design and implement ex vivo studies to evaluate CAR T-cell efficacy and safety using patient-derived samples.
• Analyze and interpret complex experimental data, present findings to internal and external partners, and contribute to scientific publications and patent applications.
• Collaborate effectively with multidisciplinary teams, including immunology, oncology, process development, and manufacturing.
• Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
• Stay abreast of innovative scientific literature and technological advancements in the CAR T-cell therapy field.
• Maintain meticulous laboratory records and adhere to all relevant safety and regulatory guidelines.

Job Qualifications

• BS or MS in Immunology, Molecular Biology, Cell Biology, Oncology, or a related field with at least 3-5+ years of relevant industry experience.
• Qualified applicants must be authorized to work in the United States on a full-time basis.