Associate Principal Scientist, Mass Spectrometry

About the role

The Analytical Enabling Capabilities organization in West Point, PA is seeking a motivated scientist with technical expertise in mass spectrometry-based protein, protein conjugation or oligonucleotides or polysaccharide characterization. In addition to mass spectrometry skills, we are also seeking candidates with strong scientific leadership, proteomics and data science skills.

Responsibilities

• Develop and perform LC-MS based assays including peptide mapping, intact mass, native mass spectrometry, proteomics, higher order structure, and host cell protein analysis or oligonucleotides or polysaccharide characterization for vaccines programs.
• Advance mass spectrometry methodology for peptide mapping, intact mass, native mass, HDX, sequence variants, glycan analysis, quantitative analysis, and host cell protein analysis.
• Represent the mass spectrometry group in project teams.
• Author technical reports and scientific presentations.
• Explore and develop new technologies to advance the field of mass spectrometry.
• Perform data processing with Genedata or other biopharma data interpretation software.
• Demonstrate effective multitasking, prioritization and problem-solving skills in the planning and execution of experiments.
• Scientific leadership and mentorship of scientists.
• Champion compliance and safety as a leader both within and outside the laboratory.

Requirements

• Minimum Requirement: PhD in Analytical Chemistry or Chemistry or relevant degree in mass spectrometry plus 5+ years of relevant experience in pharmaceutical industry.
• Candidates with MS in degree plus 8+ years or BS degree plus 12+ years of relevant industry experience.
• And Skills: A breadth and depth of analytical and vaccines development understanding, including protein, protein conjugates, oligonucleotides and polysaccharides.
• Experience in conducting mass spectrometry experiments, including sample preparation and optimization, liquid chromatography separation, mass spectrometer operation and maintenance, data interpretation, and analysis.
• Extensive knowledge of Thermo, Sciex, Agilent and Waters instruments.
• Familiarity with Genedata or other biopharma MS software.
• Excellent verbal and written communications skills, as demonstrated through high impact scientific publications and presentations.
• Experience mentoring junior scientists in pharmaceutical development.

Qualifications

• Analytical Chemistry, Analytical Method Development, Assay Development, Biological Assay Development, Cell-Based Assays, Chromatographic Techniques, High Resolution Mass Spectrometry (HRMS), Laboratory Documentation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry (MS), Mass Spectrometry Analysis, Peptide Mapping, Process Analytical Technology (PAT), Protein Analysis, Proteomics, R Programming, Secondary Ion Mass Spectrometry (SIMS), Spectrometry, Vaccine Development.

Skills

• Expertise in multiple reaction monitoring based quantitative analysis for vaccines development.
• Expertise in complex glycan analysis.
• Familiarity with R programming language for data processing, statistics and visualization.
• Advanced knowledge of electronic laboratory notebook applications and good documentation practices.