Associate Principal Scientist, Downstream Process Development
- for any list of duties/requirements/benefits, and
for prose. It doesn't forbid subheadings inside sections, but we should keep to headings only. Could embed required and preferred as separate lists within Skills section, maybe with headings inside? But better to keep simple: Skills section includes both required and preferred as bullet lists, maybe label them. Qualifications: maybe education requirements could go under Qualifications. But we already have Requirements heading for education. Could treat Requirements as education requirements, Qualifications as skills/experience? However we have both Required Skills and Preferred Skills. Could put Required Skills under Skills, Preferred Skills also under Skills but maybe separate. We need to avoid filler. Ensure we preserve all substantive info: include description of organization, role scope, responsibilities list, education requirements, required skills list, preferred skills list, salary range, benefits description. We must not include duplicated lines. The posting had duplicate "Job Description Job Description In Primary Posting Language". We'll ignore. We must not include boilerplate like EEO, accommodation, etc. We must not include application instructions (links to apply, etc). So remove those URLs. We must not include "Search Firm Representatives..." etc. We must not include "Current Employees apply HERE", etc. We must not include "US And Puerto Rico Residents Only". We must not include "The fastest way to breakthrough innovation..." etc (that's EEO fluff). Remove. We must not include "Search Firm Representatives Please Read Carefully..." etc. We must not include "Employee Status Regular Relocation: Domestic VISA Sponsorship Yes Travel Requirements 10% Flexible Work Arrangements Not Applicable Shift Not Indicated Valid Driving License No Hazardous Material(s) n/a Job Posting End Date 09/18/2026". Remove. We must not include "A job posting is effective until..." etc. We must not include "Requisition ID:R417348". Now craft HTML. Structure:
About the role
... description ...
Responsibilities
- ... ...
Requirements
Education: Ph.D. with 3+ years industry experience or Master with 6+ years industry experience or BS with 8+ years industry experience in Chemical Engineering, Biochemical engineering, or a related field.
Maybe also include "Required Skills" under Skills.Skills
Required Skills:
- Proven record of accomplishments in downstream process and technology development with a scientific publication and presentation track record.
- Scientific understanding of the engineering principles for recombinant protein purification unit operations.
- Proven ability to design and execute protein purification experiments independently.
- Ability to direct the planning, execution, analysis, and documentation of all stages of downstream process development.
- Ability to work in a matrixed team environment and collaborate with both internal and external partners including vendors
- Knowledge of biologics CMC development cycle
- Demonstrated ability for taking initiative, creativity, and innovation in problem solving
Preferred Skills:
- Experience with high throughput experimentation using automation platforms such as TECAN
- Experience using and/or programming process control systems such as DeltaV and PCS 7
- Experience with integrated and continuous processing and equipment including multi-column chromatography systems (BioSMB, PCC, or similar)
- Background or experience in data science approaches related to downstream processes and predictive modeling (multivariate data analysis, machine learning/artificial intelligence, leveraging PAT)
Benefits
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
But we must remove application instructions; the link to benefits maybe okay? It's not an application instruction, it's info about benefits. Might be okay to keep. However the instruction: remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. The benefits link is not an application instruction, it's just info. Could keep. But maybe safer to remove the URL as it could be considered navigation? It's not explicitly prohibited. The instruction says remove application instructions, not necessarily all URLs. I'd keep the benefits description but maybe drop the URL to be safe. However the benefit description includes "More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits." That's a reference; could be considered navigation but not application. I'd keep it as it's substantive info about benefits.Pay
The salary range for this role is $142,400.00 - $224,100.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We must not include filler like "commensurate with experience". This is specific. Now About the role paragraph: need to capture the description. Original: "Job Description Job Description In Primary Posting Language The Biologics Process Research & Development organization within our company's Research Laboratories is responsible for developing the drug substance manufacturing processes for our company's biologics pipeline. We work closely with colleagues in Discovery, Pre-clinical and Early Development to rapidly develop manufacturing processes for biotherapeutics and efficiently manufacture material to supply clinical trials. We are also responsible for commercial process development and the development and implementation of new manufacturing technologies. We work with our partners in the company's Manufacturing Division to commercialize and launch new products. We are seeking a highly motivated and experienced individual to join our Downstream Process Development and Engineering group as an Associate Principal Scientist. In this role, you will work with a highly collaborative team of Scientists and Engineers to design and develop downstream purification processes in support of early and late-stage biological products. The scope and activities include designing and optimization of downstream unit operations such as cell harvest, filtration, chromatography, viral clearance, precipitation, crystallization, and continuous processing for batch and intensified/continuous bioprocesses. The role will also include strategic" Then later: "Applicants should have effective organizational and multi-tasking skills and strong communication skills both verbal and presentation of data is required. A track record of leveraging data science and digital tools for delivering impactful solutions to complex problems are distinguishing. Evidence of strong cross-functional collaboration, experience successfully mentoring junior scientists, leading projects, and an external presence through scientific excellence are expected." We should incorporate that into About the role maybe. Let's craft About the role paragraph:The Biologics Process Research & Development organization within the company's Research Laboratories develops drug substance manufacturing processes for the biologics pipeline, working closely with Discovery, Pre-clinical and Early Development teams to rapidly develop manufacturing processes for biotherapeutics and supply material for clinical trials. The group also handles commercial process development and implementation of new manufacturing technologies, collaborating with the Manufacturing Division to commercialize and launch new products. As an Associate Principal Scientist in the Downstream Process Development and Engineering group, you will join a highly collaborative team of scientists and engineers to design and develop downstream purification processes for early and late-stage biological products. Responsibilities include designing and optimizing downstream unit operations such as cell harvest, filtration, chromatography, viral clearance, precipitation, crystallization, and continuous processing for batch and intensified/continuous bioprocesses, as well as contributing strategic direction. Applicants should have strong organizational and multi‑tasking abilities, excellent verbal and presentation communication skills, a track record of leveraging data science and digital tools to solve complex problems, demonstrated cross‑functional collaboration, experience mentoring junior scientists, leading projects, and an external presence through scientific excellence.
That seems to capture. Now Responsibilities list: from "Job Responsibilities The successful candidate will contribute to CMC development of our company's pipeline, playing an active role in development of downstream processes and transfer to clinical and commercial manufacturing sites. She/He will also develop strategies for process and pipeline-facing innovation. Responsibilities Include Leading biologic downstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable processes. Independently designing and conducting experiments using relevant operational parameters and analytical inputs. Providing technical supervision for process development and characterization Collaborate with upstream process development, Biologics Analytical R&D, and other cross-functional teams in both Research and Manufacturing to advance biologics pipeline. Advancing downstream platform process technical strategy, and championing creative process improvement initiatives Assessing new technologies, sciences, and industry strategies and relevance to our company Collaborating with academia, industry partners, and vendors to drive development, innovation and adoption of new process technologies Keeping up to date with the external patent and literature environment; actively presents and publishes externally and pursues patenting strategies Mentoring junior scientists" We need to split into bullet points. Let's list: - Contribute to CMC development of the company's pipeline, playing an active role in development of downstream processes and transfer to clinical and commercial manufacturing sites. - Develop strategies for process and pipeline-facing innovation. - Lead biologic downstream process development for first-in-human