Associate Principal Scientist - Biology

Neomorph is seeking an experienced drug discovery biologist to support our growing pipeline by driving programs from early discovery through IND-enabling studies. The successful applicant will collaborate across functions to establish project strategies and advance programs toward data-driven decisions.

Responsibilities

• Participate in and/or lead cross-functional teams to advance therapeutic candidates from early discovery to clinical development through strategic prioritization, interdisciplinary collaboration, and technical execution.
• Independently lead the development and execution of project-specific cellular assays to define target mechanism of action, assess pharmacodynamic response markers, and identify relevant patient populations.
• Design and implement triaging strategies to support SAR advancement and refine target compound profiles based on mechanistic understanding of biology.
• Generate and lead new target nomination, identification, and validation activities leveraging the molecular glue degrader modality.
• Anticipate, evaluate, and strategically respond to changes in the scientific, competitive, or regulatory landscape.
• Communicate scientific advancements, strategic shifts, and risk assessments to project stakeholders.
• Contribute to Neomorph’s culture of scientific rigor, collaboration, and continuous learning by sharing expertise and mentoring junior scientists.

Requirements

• PhD with 6+ years, MS with 9+ years, or BS with 11+ years of industry experience.
• Track record of strategically advancing preclinical drug discovery programs with robust data packages.
• Experience independently developing and implementing reproducible SAR-enabling assay cascades.
• Experience managing a team, including directing and coaching employees.
• Experience participating in and/or leading cross-functional teams.
• Excellent verbal, written, and interpersonal communication skills.
• Desire and capacity to work in a dynamic, fast-paced, and collaborative research setting.

Preferred Qualifications

• Experience with targeted protein degradation.
• Experience managing teams of one or more associate scientists.

Benefits

• Industry-competitive compensation and annual target bonus.
• Stock options and 401K plan.
• Comprehensive medical, dental, and vision plans for employees and dependents.
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution.
• Employee Assistance Program.
• 10 holidays + Winter Shutdown + 3 weeks of vacation (additional accruals after 2 years), separate sick leave.
• Supplemental pay for Pregnancy Disability Leave.
• Paid Parental Leave for employees with a newborn or newly adopted/fostered child.
• Volunteer days off for community contributions.
• Flexible work schedule and casual work environment.
• Access to onsite gym and bicycle/surfboard storage.
• Regular company-wide and department social events (e.g., happy hours, lunches, Padres games, summer picnic, holiday party, bring-your-kids-to-work day).

About Us

Neomorph is a venture-backed biotechnology company focused on discovering and developing innovative medicines against ‘undruggable targets’ through protein degradation and molecular glues. Our team consists of industry-leading experts with a track record of groundbreaking discoveries. We are committed to advancing the science of molecular glue drug discovery while prosecuting a pipeline of projects through clinical development. Headquartered in San Diego, California, Neomorph fosters a patient-first, science-driven, and collaborative work environment.