Associate Director, Study Toxicologist

About the role

Madrigal is seeking an Associate Director, Study Toxicologist to support nonclinical development programs for metabolic dysfunction–associated steatohepatitis (MASH).

Responsibilities

• Support the design and execution of nonclinical studies, including toxicology, PK, ADME, and bioanalytical studies.
• Provide scientific oversight of outsourced studies, including protocol input, study monitoring, data review, and final report review.
• Coordinate study placement and management at CROs, including vendor interaction, study startup, and timeline tracking.
• Monitor study conduct at external vendors to ensure quality and alignment with program timelines and objectives.
• Review and interpret study data and reports for accuracy, completeness, and scientific rigor.
• Partner closely with Nonclinical Development program leads and cross-functional teams to support integrated development plans and contribute scientific input to nonclinical development strategy as appropriate.
• Maintain clear communication with internal stakeholders and external partners throughout study execution.

Qualifications

• PhD (or equivalent) in Toxicology, Pharmacology, DMPK, or a related scientific discipline.
• Relevant pharmaceutical or biotechnology industry experience supporting nonclinical development programs and 10+ years of relevant experience.
• Experience managing outsourced nonclinical studies with CROs, including protocol and report review.
• Strong attention to detail and ability to manage multiple studies simultaneously.
• Excellent written and verbal communication skills.

Preferred

• Experience with small molecule and/or siRNA programs.
• Experience supporting late-stage nonclinical studies, including reproductive and developmental toxicology (DART) and carcinogenicity studies.