Associate Director, Data Science

About the role

Novartis is a leader in data science and model-informed drug development. We are seeking an experienced Data Science leader to advance data-driven drug discovery and development by integrating advanced analytics, machine learning, and mechanistic modelling approaches.

Responsibilities

• Shape and advance AI-driven MIDD by integrating mechanistic modelling and machine learning to bridge biology and clinical outcomes.
• Design and implement hybrid modelling pipelines where mechanistic simulations generate features for machine learning models.
• Translate model-derived biomarkers and mechanistic states into clinically relevant predictions and decision-support tools.
• Drive scientifically grounded AI approaches that enhance mechanistic understanding, ensuring rigor, interpretability, and robustness.
• Develop scalable, reproducible workflows integrating data science, mechanistic modelling, and in-house tools.
• Define and implement project-specific in silico modelling and data strategies aligned with key decision questions.
• Apply and advance currently available data mining and advanced analytics to link molecular structure, ADME properties, and pharmacological outcomes across modalities.
• Drive adoption and effective use of in silico models, tools, and data to accelerate decision-making.
• Collaborate with PKS, Translational Medicine, and Data & Digital teams to integrate diverse datasets (preclinical, clinical, external).
• Contribute to translational programs across disease areas and communicate modelling insights to influence decision-making.
• Stay current with advances in AI/ML and their application to ADME, PK/PD, and drug discovery and development, and proactively evaluate and bring appropriate innovation into practice to improve efficiency and scientific impact.

Requirements

• Advanced degree in life sciences or quantitative discipline (e.g., data science, computational biology, pharmacometrics, bioinformatics, computational chemistry, biomedical engineering or related field).
• PhD with 5+ years or MSc with 8+ years of relevant experience in drug discovery or development.
• Strong expertise in machine learning, statistics, and data science methods.
• Demonstrated experience applying reproducible data science approaches to drug discovery or development.
• Experience combining mechanistic modelling and data-driven approaches is strongly preferred.
• Strong understanding of ADME, PK/PD, and/or translational modelling concepts.
• Proficiency in Python and/or R, including software development best practices (version control, testing, documentation).
• Experience with machine learning libraries such as scikit-learn, PyTorch, or Keras.
• Strong data visualization and exploratory data analysis skills.
• Able to translate complex analytical concepts into clear, actionable insights.
• Strong collaboration and communication skills across multidisciplinary teams.
• Fluency in English (oral and written).

Pay

The salary for this position is expected to range between $160,300 and $297,700 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Schedule

This is a hybrid role that requires a balance of in-person and virtual working, with an average of 12 days a month on site in Cambridge, MA.