Analytical Development Synthetic Molecules Characterization Scientist

About the role

The Scientist Analytical Development – Synthetic Molecules Characterization is responsible for leading scientific and technical work within Analytical Development, with a strong focus on the characterization of synthetic molecules, including peptides and PROTACs. In this role, you will support the transition of novel compounds from Discovery into Development and into first-in-human clinical studies. You will also contribute to ongoing research across the development lifecycle, with emphasis on salt and polymorph screening, solid-state analytics, and analytical method development for Drug Substance and Drug Product.

Responsibilities

• Independently design, plan, and execute studies to define the physicochemical properties and behavior of new development candidates that support lead candidate selection and downstream Chemistry, Manufacturing, and Controls development.
• Lead and contribute to solid-state screening activities, including salt and polymorph.
• Drive physicochemical profiling efforts and analytical method development for Drug Substance and Drug Product.
• Develop fit-for-purpose chromatographic methods for analysis.
• Work closely with colleagues in Discovery, Drug Safety, Drug Metabolism and Pharmacokinetics, Process Chemistry, Formulation Development, and Late Phase Analytical Development to support project goals.
• Provide technical leadership within projects and support strategy development across projects and functions.
• Serve as a technical expert and mentor for junior team members when needed.
• Integrate scientific and technical work across functions to address project issues and support solutions.
• Plan and implement resolutions to technical problems and support local technical or process initiatives.
• Author technical reports and contribute to regulatory filings.

Qualifications

Bachelor’s degree in Pharmaceutics, analytical chemistry, organic chemistry, or a related pharmaceutical science, with 8 or more years of relevant industry experience; or Master’s degree in Pharmaceutics, physical organic chemistry, analytical chemistry, or a related pharmaceutical science, with 6 or more years of relevant industry experience; or PhD in a relevant discipline with no minimum industry experience.

Skills

• Strong understanding of polymorphism and solid-state screening techniques.
• Strong understanding of solid-state analytical techniques, including X-ray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, dynamic vapor sorption, microscopy, and spectroscopic analysis.
• Strong understanding of analytical method development, including high-performance liquid chromatography, gas chromatography, Karl Fischer, and dissolution testing.
• Hands-on experience in multiple analytical techniques, along with strong knowledge of analytical theory, and proven ability to work in a Good Manufacturing Practice laboratory setting.
• Ability to troubleshoot complex scientific and technical issues, identify root causes, and implement practical solutions.
• Experience working in highly cross-functional teams and sharing knowledge across groups.
• Strong technical writing skills for internal documents and regulatory support.
• Ability to organize work, manage priorities