AI/ML Scientist
Manifold Bio · San Francisco Bay Area · 1 wk ago
Engineering$140k–$225k/yrFull-time
Responsibilities
- Lead independent research projects exploring novel AI/ML approaches for protein design and optimization
- Investigate and integrate novel data types to enhance our binder design capabilities and therapeutic development
- Develop and validate cutting-edge machine learning methodologies for molecular engineering applications
- Mentor and guide junior scientists and engineers in advanced ML techniques and research methodologies
- Drive strategic research planning and identify promising new directions for AI-driven drug discovery
- Lead cross-functional teams to translate research breakthroughs into therapeutic applications
- Provide scientific expertise for business development opportunities and strategic partnerships
Required Qualifications
- PhD in Machine Learning, Computational Biology, Bioinformatics, Computer Science, or related field
- 5+ years of industry experience in machine learning research, preferably in biotechnology or pharmaceutical settings
- Expert-level proficiency in PyTorch and/or JAX with extensive experience in novel architecture development
- Deep expertise in protein structure analysis, molecular dynamics, computational biology, or structural bioinformatics
- Extensive knowledge of modern AI advances in protein analysis, design, and optimization
- Advanced understanding of deep learning architectures, particularly transformers for molecular applications, as well as generative modeling approaches (autoregressive, diffusion, flow-matching, etc.)
- Proven experience leading research teams and mentoring junior scientists
- Strong background in statistical analysis, experimental design, and rigorous scientific methodology
- Experience with distributed computing, high-performance computing, and large-scale ML system design
- Outstanding written and verbal communication skills with experience presenting to scientific and business audiences
- Demonstrated ability to translate research innovations into practical applications
Preferred Qualifications
- Previous experience in biotech/pharma industry with focus on AI-driven drug discovery
- Knowledge of protein engineering, directed evolution, or structural biology wet lab techniques
- Experience with large-scale data engineering, cloud platforms, and production ML systems
- Demonstrated track record of published research in top-tier ML, computational biology, or protein design journals
- Track record of successful grant funding and research proposal writing
- Experience with regulatory considerations for AI applications in therapeutic development
- Strong network within the computational biology and protein design research communities
- Demonstrated leadership in cross-functional scientific teams
- Experience with intellectual property development and patent applications
Pay
Base Salary Range: $140,000-225,000
This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.
Benefits
- Annual performance-based target bonus
- Stock options
- Comprehensive medical, dental, and vision coverage
- 401(k) plan
- Flexible paid time off and holidays
- Perks including on-site gym, onsite lunch, and commuter support
Schedule
This is an on-site role and can be based in either Boston, Massachusetts or San Francisco, California. Please only apply if you reside in these cities or are open to relocating.