ADME Project Leadership for Genetic Medicines

Job Summary

Lilly is seeking a skilled ADME / DMPK scientist to lead and innovate in a multidisciplinary team environment. The ideal candidate will have a strong background in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles, especially as they relate to novel genetic medicine therapeutic modalities.

Responsibilities

• Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
• Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
• Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies
• Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
• Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
• Mentor and support junior scientists and build relationships through coaching and mentorship with fellow scientists at all levels

Qualifications

• Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field
• Greater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PD
• Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeutics
• Experience with PK/PD modeling and simulation
• Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
• Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology

Benefits

Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).